Journal of Medical Surgical and Allied Sciences, Volume 3, Issue 2 : 8-14 . Doi : 10.37446/jmedsurg/rsa/3.2.2025.8-14

Research Article

OPEN ACCESS | Published on : 31-Dec-2025

Assessment of viral load and liver enzymes levels among infected individuals with hepatitis B virus in Kassala State, Sudan

Omer Osman Mohamed
• Department of Medical Laboratories, Almumayaz Advance Medical Laboratories, Wad Medani, Sudan.


• Khalid Abdelsamea Mohamedahmed
• Department of Hematology and Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan. khalid.gu89@gmail.com.; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jerash University, Jerash, Jordan. khalid.gu89@gmail.com.

Mohamed Elnaeem Barakat
• Department of Medical Laboratories, Almumayaz Advance Medical Laboratories, Wad Medani, Sudan.

Mohammed Aldai Hammad
• Department of Medical Laboratories, Dar eloloum College for Science and Technology, Kassala, Sudan.

Rida Abdalnaser Awad
• Department of Medical Laboratories, Wad Medani Police Hospital, Wad Medani, Sudan.

Hani M. Abdalla
• Department of Medical Laboratories, Health Services Directorate, University of Gezira, Wad Medani, Sudan.

Abstract

Background: Hepatitis B Virus (HBV) is a major global health issue, affecting over 296 million people worldwide. This study aimed to assess the relationship between viral load and liver enzyme levels among HBV-infected individuals in Kassala State, Sudan.

Methods: A cross-sectional study was conducted from August to November 2024 in Kassala State. Data were collected from 50 HBV-positive individuals using a structured questionnaire. Viral load was measured via quantitative PCR, and liver enzyme levels (ALT, AST, and ALP) were analyzed using standard biochemical assays. Data analysis was performed using SPSS version 22.

Results: The study population consisted of 50% males and 50% females. Significant correlations were found between viral load and liver enzymes: ALT (r=0.833, p=0.000), AST (r=0.733, p=0.000), and ALP (r=0.586, p=0.000). Gender analysis revealed higher viral loads in females (p=0.044). No significant associations were observed between viral load and marital status (p=0.905), age (p=0.985), or duration of infection (p=0.960).

Conclusion: Elevated viral load was associated with increased liver enzyme levels, particularly in females. Routine viral load and liver enzyme monitoring are recommended to improve HBV management.

Keywords

Hepatitis B Virus (HBV), Viral Load, Liver Enzymes, Sudan

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