Background: Gram-negative pathogens, notably Klebsiella pneumoniae, pose a global challenge due to their propensity for multidrug resistance, particularly in nosocomial infections like urinary tract infections (UTIs). Antimicrobial stewardship programs (ASPs) have been instituted to address the rampant misuse of antibiotics, aiming to foster judicious prescribing practices. This study evaluates the impact of an ASP on antibiotic sensitivity patterns of K. pneumoniae in a tertiary care hospital in Central India.
Methods: Urine samples positive for K. pneumoniae collected during 2023 and 2024 were subjected to antimicrobial susceptibility testing.
Results: Results demonstrate significant improvements in sensitivity patterns, notably in carbapenems and chloramphenicol. These findings underscore the effectiveness of ASPs in guiding antibiotic prescribing practices, attributed to enhanced acceptance among healthcare professionals.
Conclusion: Sustained initiatives to encourage responsible antibiotic utilization and garner support from healthcare professionals remain crucial in effectively tackling antibiotic resistance. Additionally, further research is needed to assess the long-term viability and scalability of such interventions.
antibiotics, gram negative bacilli, urine
Aiesh, B. M., Nazzal, M. A., Abdelhaq, A. I., Abutaha, S. A., Zyoud, S. E. H., & Sabateen, A. (2023). Impact of an antibiotic stewardship program on antibiotic utilization, bacterial susceptibilities, and cost of antibiotics. Scientific Reports, 13(1), 5040.
Chaudhary, B. L., Shailja Srivastava, S. S., Singh, B. N., & Snehanshu Shukla, S. S. (2014). Nosocomial infection due to multidrug resistant (MDR) Escherichia coli and Klebsiella pneumoniae in intensive care unit. International Journal of Current Microbiology and Applied Sciences, 3(8), 630-635.
Kumar, A. R. (2013). Antimicrobial sensitivity pattern of Klebsiella pneumonia isolated from pus from tertiary care hospital and issues related to the rational selection of antimicrobials.
Nathwani, D., Varghese, D., Stephens, J., Ansari, W., Martin, S., & Charbonneau, C. (2019). Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review. Antimicrobial Resistance & Infection Control, 8, 1-13.
Shilpa, K., Kedam, T., & Ramyashree, A. (2016). Isolation and antimicrobial sensitivity pattern of Klebsiella pneumoniae from sputum samples in a tertiary care hospital. International Journal of Biomedical and Advance Research, 7(2), 53. https://doi.org/10.7439/ijbar.v7i2.2945
