One of the main causes of death for women is breast cancer. Surgery, radiation therapy, and chemotherapy are common forms of treatment, and they have a number of adverse effects. Sulforaphane (SFP) is a naturally occurring isothiocyanate that can be found in cauliflower, broccoli, and other vegetables. It exhibits potential anticancer activity against breast, pancreatic, bladder, hepatic, prostate, osteosarcoma, melanoma. In order to demonstrate its targeted medication delivery utilizing a magnetic field, magnetic nanoparticles are essential. This study's primary objective was to investigate how magnetic nanoparticles can improve bioavailability, stability, and dissolution. By encapsulating a herbal medication called SFP in iron salts, the magnetic nanoparticles were developed. They were then characterized using FTIR, XRD, SEM, TGA, drug loading efficiency, zeta potential, VSM, and stability studies. In-vitro dissolution and in-vitro anticancer activity were conducted to determine which formulation was the best among them using MDA-MB-231 cells. According to HRSEM data, the average particle size of MNPs 100–250 nm following loading with sulforaphane had a consistent spherical shape. At pH 6, the zeta potential value was determined to be 15 mv and -9 mv, respectively. According to in-vitro dissolution studies, pH has an impact on the amount of drug release. that all four varieties of magnetic nanoparticles exhibit adequate magnetic response for drug targeting in the presence of an external magnetic field, have a good size range, a high surface area, and a sufficient percentage of elements on their particle surface. SFP/MCM-41MNP (F2) shown more cytotoxicity on MDA-MB-231 cells than other positive control groups and pure SFP, according to the MTT-assay. The IC50 of F2 was close to that of standard Doxorubicin. Hence it was considered as best formulation, useful for the effective management of breast cancer.
Sulforaphane, FTIR, Loading Efficiency, dissolution study, MDA-MB-231
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